PDBe 2y1m

X-ray diffraction
2.67Å resolution

Structure of native c-Cbl

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase CBL Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 389 amino acids
Theoretical weight: 44.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22681 (Residues: 47-435; Coverage: 43%)
Gene names: CBL, CBL2, RNF55
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 146.8Å b: 148.56Å c: 348.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.263
Expression system: Escherichia coli BL21(DE3)