PDBe 2xnx

X-ray diffraction
3.3Å resolution

BC1 fragment of streptococcal M1 protein in complex with human fibrinogen

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 14-mer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
M PROTEIN Chains: M, N
Molecule details ›
Chains: M, N
Length: 146 amino acids
Theoretical weight: 17.26 KDa
Source organism: Streptococcus pyogenes
Expression system: Escherichia coli BL21
Fibrinogen beta chain Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 328 amino acids
Theoretical weight: 37.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02675 (Residues: 164-491; Coverage: 71%)
Gene name: FGB
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:
Fibrinogen alpha chain Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 87 amino acids
Theoretical weight: 10.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02671 (Residues: 130-216; Coverage: 10%)
Gene name: FGA
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Fibrinogen gamma chain Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 319 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02679 (Residues: 114-432; Coverage: 75%)
Gene names: FGG, PRO2061
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 112.723Å b: 216.866Å c: 140.807Å
α: 90° β: 102.54° γ: 90°
R-values:
R R work R free
0.279 0.277 0.325
Expression system: Escherichia coli BL21