PDBe 2xiq

X-ray diffraction
1.95Å resolution

Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylmalonyl-CoA mutase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 762 amino acids
Theoretical weight: 84.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22033 (Residues: 12-750; Coverage: 99%)
Gene names: MMUT, MUT
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand B12 2 x B12
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 75.65Å b: 143.62Å c: 163.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.161 0.201
Expression system: Escherichia coli BL21(DE3)