PDBe 2x89

X-ray diffraction
2.16Å resolution

Structure of the Beta2_microglobulin involved in amyloidogenesis

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
R2 protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 128 amino acids
Theoretical weight: 14.16 KDa
Source organism: Camelus dromedarius
Expression system: Escherichia coli
UniProt:
  • Canonical: A2KD59 (Residues: 1-60, 61-102, 103-114, 115-128; Coverage: 97%)
Gene name: r2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Beta-2-microglobulin Chains: D, E, F, G
Molecule details ›
Chains: D, E, F, G
Length: 94 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 27-119; Coverage: 94%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 77.49Å b: 100.864Å c: 83.743Å
α: 90° β: 106.43° γ: 90°
R-values:
R R work R free
0.24 0.238 0.267
Expression system: Escherichia coli