PDBe 2x38

X-ray diffraction
2.2Å resolution

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.


Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 142.42Å b: 64.66Å c: 116.9Å
α: 90° β: 103.39° γ: 90°
R R work R free
0.24 0.239 0.277
Expression system: Spodoptera frugiperda