PDBe 2x1x

X-ray diffraction
3.1Å resolution

CRYSTAL STRUCTURE OF VEGF-C IN COMPLEX WITH DOMAINS 2 AND 3 OF VEGFR2 IN A TETRAGONAL CRYSTAL FORM

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vascular endothelial growth factor C Chain: E
Molecule details ›
Chain: E
Length: 110 amino acids
Theoretical weight: 12.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49767 (Residues: 112-215; Coverage: 27%)
Gene name: VEGFC
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines
Vascular endothelial growth factor receptor 2 Chain: R
Molecule details ›
Chain: R
Length: 213 amino acids
Theoretical weight: 23.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35968 (Residues: 120-328; Coverage: 16%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P42212
Unit cell:
a: 88.733Å b: 88.733Å c: 105.273Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.266 0.334
Expression system: Spodoptera frugiperda