PDBe 2wy3

X-ray diffraction
1.8Å resolution

Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein UL16 Chains: B, D
Molecule details ›
Chains: B, D
Length: 158 amino acids
Theoretical weight: 17.74 KDa
Source organism: Human herpesvirus 5 strain AD169
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16757 (Residues: 27-184; Coverage: 78%)
Gene name: UL16
Structure domains: Immunoglobulin-like
MHC class I polypeptide-related sequence B Chains: A, C
Molecule details ›
Chains: A, C
Length: 319 amino acids
Theoretical weight: 36.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q29980 (Residues: 24-341; Coverage: 88%)
Gene names: MICB, PERB11.2
Sequence domains:
Structure domains: MHC class I-like antigen recognition-like

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 58.12Å b: 104.17Å c: 146.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.213
Expression systems:
  • Cricetulus griseus
  • Escherichia coli