PDBe 2wwj

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed:
(1a) [protein]-N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = [protein]-N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 4A Chains: A, B
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 40.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75164 (Residues: 7-353; Coverage: 33%)
Gene names: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
Sequence domains:
Structure domains: Cupin

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 101.33Å b: 148.97Å c: 57.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.178 0.248
Expression system: Escherichia coli BL21(DE3)