PDBe 2ws6

X-ray diffraction
1.5Å resolution

Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assemblies composition:
hetero 12-mer
hetero hexamer (preferred)
hetero tetramer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Insulin A chain Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Insulin B chain Chains: F, H, J, L
Molecule details ›
Chains: F, H, J, L
Length: 30 amino acids
Theoretical weight: 3.45 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 58.962Å b: 61.927Å c: 47.297Å
α: 90° β: 111.9° γ: 90°
R-values:
R R work R free
0.152 0.15 0.2
Expression system: Not provided