PDBe 2ws4

X-ray diffraction
1.9Å resolution

Semi-synthetic analogue of human insulin ProB26-DTI in monomer form

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 2.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-49; Coverage: 29%)
Gene name: INS

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: I422
Unit cell:
a: 57.832Å b: 57.832Å c: 54.842Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.278
Expression system: Not provided