PDBe 2wqa

X-ray diffraction
2.85Å resolution

Complex of TTR and RBP4 and Oleic Acid

Released:
Source organism: Homo sapiens
Entry authors: Nanao M, Mercer D, Nguyen L, Buckley D, Stout TJ

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 129 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain
Retinol-binding protein 4 Chains: E, F
Molecule details ›
Chains: E, F
Length: 177 amino acids
Theoretical weight: 20.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P02753 (Residues: 19-194; Coverage: 96%)
Gene names: PRO2222, RBP4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P41
Unit cell:
a: 138.662Å b: 138.662Å c: 122.789Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.253
Expression systems:
  • Escherichia coli
  • Trichoplusia ni