PDBe 2wg3

X-ray diffraction
2.6Å resolution

Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Desert hedgehog protein N-product Chains: A, B
Molecule details ›
Chains: A, B
Length: 164 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O43323 (Residues: 40-194; Coverage: 41%)
Gene name: DHH
Structure domains: Muramoyl-pentapeptide Carboxypeptidase; domain 2
Hedgehog-interacting protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 463 amino acids
Theoretical weight: 51.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: Q96QV1 (Residues: 214-672; Coverage: 67%)
Gene names: HHIP, HIP, UNQ5825/PRO19644
Sequence domains: Glucose / Sorbosone dehydrogenase
Structure domains: Laminin

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 102.821Å b: 110.701Å c: 144.381Å
α: 90° β: 90° γ: 90°
R R work R free
0.227 0.224 0.281
Expression systems:
  • Escherichia coli
  • Homo sapiens