PDBe 2wbj

X-ray diffraction
3Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 194 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 26-218; Coverage: 84%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-15 beta chain Chains: B, F
Molecule details ›
Chains: B, F
Length: 200 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01911 (Residues: 30-228; Coverage: 84%)
Gene names: HLA-DRB1, HLA-DRB2
Sequence domains:
Structure domains:
OB TCR Chains: C, G
Molecule details ›
Chains: C, G
Length: 219 amino acids
Theoretical weight: 24.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
Structure domains: Immunoglobulins
OB TCR Chains: D, H
Molecule details ›
Chains: D, H
Length: 279 amino acids
Theoretical weight: 30.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 109.706Å b: 130.271Å c: 180.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.288
Expression systems:
  • Drosophila melanogaster
  • Escherichia coli BL21(DE3)