PDBe 2way

X-ray diffraction
2.3Å resolution

Structure of the human DDX6 C-terminal domain in complex with an EDC3- FDF peptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Probable ATP-dependent RNA helicase DDX6 Chains: A, C
Molecule details ›
Chains: A, C
Length: 193 amino acids
Theoretical weight: 22.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26196 (Residues: 293-483; Coverage: 40%)
Gene names: DDX6, HLR2, RCK
Sequence domains: Helicase conserved C-terminal domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Enhancer of mRNA-decapping protein 3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 44 amino acids
Theoretical weight: 5.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96F86 (Residues: 190-228; Coverage: 8%)
Gene names: EDC3, LSM16, PP844, YJDC, YJEFN2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 46.92Å b: 80.46Å c: 110.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.21 0.275
Expression system: Escherichia coli