PDBe 2w8r

X-ray diffraction
2.4Å resolution

The crystal structure of human SSADH in complex with NAD+

Released:
Source organism: Homo sapiens
Primary publication:
Redox-switch modulation of human SSADH by dynamic catalytic loop.
EMBO J. 28 959-68 (2009)
PMID: 19300440

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo 12-mer
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Succinate-semialdehyde dehydrogenase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 487 amino acids
Theoretical weight: 52.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51649 (Residues: 49-535; Coverage: 91%)
Gene names: ALDH5A1, SSADH
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: F432
Unit cell:
a: 265.925Å b: 265.925Å c: 265.925Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.263
Expression system: Escherichia coli