PDBe 2vzg

X-ray diffraction
1.8Å resolution

Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD2 motif


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Paxillin Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P49023 (Residues: 141-160; Coverage: 3%)
Gene name: PXN
Alpha-parvin Chain: B
Molecule details ›
Chain: B
Length: 131 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9NVD7 (Residues: 242-372; Coverage: 35%)
Gene names: MXRA2, PARVA
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 74.008Å b: 94.422Å c: 41.841Å
α: 90° β: 90° γ: 90°
R R work R free
0.187 0.186 0.221
Expression systems:
  • Escherichia coli BL21
  • Not provided