PDBe 2vr6

X-ray diffraction
1.3Å resolution

Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.3 A resolution


Function and Biology Details

Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Superoxide dismutase [Cu-Zn] Chains: A, F
Molecule details ›
Chains: A, F
Length: 153 amino acids
Theoretical weight: 15.93 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
  • Canonical: P00441 (Residues: 2-154; Coverage: 99%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 35.296Å b: 73.746Å c: 111.424Å
α: 90° β: 90° γ: 90°
R R work R free
0.135 0.132 0.182
Expression system: Saccharomyces cerevisiae