PDBe 2vnf

X-ray diffraction
1.76Å resolution

MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibitor of growth protein 4 Chains: A, C
Molecule details ›
Chains: A, C
Length: 60 amino acids
Theoretical weight: 6.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW Q9UNL4 (Residues: 188-246; Coverage: 24%)
Gene names: ING4, My036
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)
Histone H3.1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 10 amino acids
Theoretical weight: 1.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P68431 (Residues: 2-11; Coverage: 7%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P43
Unit cell:
a: 68.516Å b: 68.516Å c: 28.174Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.156 0.227
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided