PDBe 2vlr

X-ray diffraction
2.3Å resolution

The Structural Dynamics and Energetics of an Immunodominant T-cell Receptor are Programmed by its Vbeta Domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Matrix protein 1 Chains: C, H
Molecule details ›
Chains: C, H
Length: 9 amino acids
Theoretical weight: 966 Da
Source organism: unidentified influenza virus
Expression system: Not provided
UniProt:
  • Canonical: P03485 (Residues: 58-66; Coverage: 4%)
Gene name: M
JM22 TCR BETA CHAIN Chains: E, J
Molecule details ›
Chains: E, J
Length: 244 amino acids
Theoretical weight: 27.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Beta-2-microglobulin Chains: B, G
Molecule details ›
Chains: B, G
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
JM22 TCR ALPHA CHAIN Chains: D, I
Molecule details ›
Chains: D, I
Length: 201 amino acids
Theoretical weight: 22.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
HLA class I histocompatibility antigen, A-2 alpha chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01892 (Residues: 25-300; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P1
Unit cell:
a: 48.622Å b: 95.523Å c: 122.045Å
α: 110.29° β: 98.64° γ: 93.59°
R-values:
R R work R free
0.222 0.219 0.281
Expression systems:
  • Not provided
  • Escherichia coli