› 2v5n

X-ray diffraction
3.2Å resolution

STRUCTURE OF HUMAN IGF2R DOMAINS 11-12

Released:
DOI: 10.2210/pdb2v5n/pdb
PDB entry 2v5n coloured by chain, front view.
PDB entry 2v5n coloured by chain, side view.
PDB entry 2v5n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functional analysis of the IGF-II/IGF2R interaction.
Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY
EMBO J 27 265-76 (2008)
PMID: 18046459

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cation-independent mannose-6-phosphate receptor Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 32.98 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P11717 (Residues: 1508-1800; Coverage: 12%)
Gene names: IGF2R, MPRI
Sequence domains: Cation-independent mannose-6-phosphate receptor repeat
Structure domains: Mannose-6-phosphate receptor binding domain

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P6122
Unit cell:
a: 64.793Å b: 64.793Å c: 269.569Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.259 0.253 0.317
Expression system: Cricetulus griseus

Quick links

Citations

16 review citations

Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.
Rich et al. (2010)
15 more

3 mentions without citation

Structure and functional analysis of the IGF-II/IGF2R interaction.
Brown et al. (2008)
2 more