PDBe 2uz9

X-ray diffraction
2.3Å resolution

Human guanine deaminase (guaD) in complex with zinc and its product Xanthine.

Source organism: Homo sapiens
Entry authors: Moche M, Welin M, Arrowsmith C, Berglund H, Busam R, Collins R, Dahlgren LG, Edwards A, Flodin S, Flores A, Graslund S, Hammarstrom M, Hallberg BM, Holmberg-Schiavone L, Johansson I, Kallas A, Karlberg T, Kotenyova T, Lehtio L, Nyman T, Ogg D, Persson C, Sagemark J, Stenmark P, Sundstrom M, Thorsell AG, van den berg S, Weigelt J, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
Guanine + H(2)O = xanthine + NH(3)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Guanine deaminase Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 53.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9Y2T3 (Residues: 1-454; Coverage: 100%)
Gene names: GDA, KIAA1258
Sequence domains: Amidohydrolase family
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: C2
Unit cell:
a: 91.735Å b: 85.713Å c: 78.96Å
α: 90° β: 116.49° γ: 90°
R R work R free
0.172 0.169 0.222
Expression system: Escherichia coli BL21(DE3)