PDBe 2uxw

X-ray diffraction
1.45Å resolution

Crystal structure of human very long chain acyl-CoA dehydrogenase (ACADVL)

Released:
Source organism: Homo sapiens
Entry authors: Pike ACW, Hozjan V, Smee C, Berridge G, Burgess N, Salah E, Bunkoczi G, Uppenberg J, Ugochukwu E, von Delft F, Arrowsmith CH, Edwards A, Weigelt J, Sundstrom M, Oppermann U

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 607 amino acids
Theoretical weight: 65.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49748 (Residues: 69-655; Coverage: 90%)
Gene names: ACADVL, VLCAD
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 75.001Å b: 108.173Å c: 149.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.149 0.148 0.17
Expression system: Escherichia coli BL21(DE3)