PDBe 2seb

X-ray diffraction
2.5Å resolution

X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Enterotoxin type B Chain: D
Molecule details ›
Chain: D
Length: 239 amino acids
Theoretical weight: 28.41 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: P01552 (Residues: 28-266; Coverage: 100%)
Gene name: entB
Sequence domains:
Structure domains:
Chondrocalcin Chain: E
Molecule details ›
Chain: E
Length: 12 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02458 (Residues: 1238-1247; Coverage: 1%)
Gene name: COL2A1
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-4 beta chain Chain: B
Molecule details ›
Chain: B
Length: 192 amino acids
Theoretical weight: 22.52 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P13760 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 78.53Å b: 100.28Å c: 100.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.28
Expression system: Drosophila