PDBe 2rr9

Solution NMR

The solution structure of the K63-Ub2:tUIMs complex

Released:
Source organism: Homo sapiens
Entry authors: Sekiyama N, Jee J, Isogai S, Akagi K, Huang T, Ariyoshi M, Tochio H, Shirakawa M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquitin Chains: A, B
Molecule details ›
Chains: A, B
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
BRCA1-A complex subunit RAP80 Chain: C
Molecule details ›
Chain: C
Length: 46 amino acids
Theoretical weight: 5.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RL1 (Residues: 79-124; Coverage: 6%)
Gene names: RAP80, RXRIP110, UIMC1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli