PDBe 2rfe

X-ray diffraction
2.9Å resolution

Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: NEW P00533 (Residues: 702-1022; Coverage: 27%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine kinase
Structure domains:
ERBB receptor feedback inhibitor 1 Chains: E, F
Molecule details ›
Chains: E, F
Length: 40 amino acids
Theoretical weight: 4.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: NEW Q9UJM3 (Residues: 325-364; Coverage: 9%)
Gene names: ERRFI1, MIG6

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: P21
Unit cell:
a: 90.508Å b: 98.425Å c: 101.496Å
α: 90° β: 112.59° γ: 90°
R R work R free
0.229 0.229 0.271
Expression systems:
  • Spodoptera frugiperda
  • Not provided