PDBe 2r7e

X-ray diffraction
3.7Å resolution

Crystal Structure Analysis of Coagulation Factor VIII

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor VIIIa heavy chain, 92 kDa isoform Chain: A
Molecule details ›
Chain: A
Length: 742 amino acids
Theoretical weight: 84.95 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00451 (Residues: 19-760; Coverage: 32%)
Gene names: F8, F8C
Sequence domains:
Structure domains: Cupredoxins - blue copper proteins
Factor VIIIa light chain Chain: B
Molecule details ›
Chain: B
Length: 770 amino acids
Theoretical weight: 88.92 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00451 (Residues: 1582-2351; Coverage: 33%)
  • Best match: P00451-2 (Residues: 9-216)
Gene names: F8, F8C
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2, ALS BEAMLINE 5.0.1
Spacegroup: P41212
Unit cell:
a: 134.569Å b: 134.569Å c: 359.496Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.279 0.347
Expression system: Cricetulus griseus