PDBe 2r0w

X-ray diffraction
2.5Å resolution

PFA2 FAB complexed with Abeta1-8

Released:
Source organisms:
Primary publication:
Molecular basis for passive immunotherapy of Alzheimer's disease.
Proc. Natl. Acad. Sci. U.S.A. 104 15659-64 (2007)
PMID: 17895381

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-amyloid protein 40 Chain: Q
Molecule details ›
Chain: Q
Length: 8 amino acids
Theoretical weight: 978 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-679; Coverage: 1%)
Gene names: A4, AD1, APP
If kappa light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.2 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-219; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
Structure domains: Immunoglobulins
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 24.02 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q811U5 (Residues: 1-99, 100-118; Coverage: 100%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 42.793Å b: 43.327Å c: 58.456Å
α: 92.51° β: 94.96° γ: 90.55°
R-values:
R R work R free
0.211 0.208 0.277
Expression system: Not provided