› 2qmq

X-ray diffraction
1.7Å resolution

Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution

Released:
DOI: 10.2210/pdb2qmq/pdb
PDB entry 2qmq coloured by chain, front view.
PDB entry 2qmq coloured by chain, side view.
PDB entry 2qmq coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon AM, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH
J Biol Chem 286 12450-60 (2011)
PMID: 21247902

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein NDRG2 Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 32.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9QYG0 (Residues: 40-313; Coverage: 74%)
Gene names: Kiaa1248, Ndr2, Ndrg2
Sequence domains: Ndr family
Structure domains: alpha/beta hydrolase

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand BEZ 1 x BEZ
Ligand 2PE 1 x 2PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 46.371Å b: 46.371Å c: 214.749Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.147 0.145 0.183
Expression system: Escherichia coli

Quick links

Citations

7 review citations

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms.
Adrain et al. (2012)
6 more

2 mentions without citation

Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
Hwang et al. (2011)
1 more