PDBe 2q5d

X-ray diffraction
3.2Å resolution

Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form

Released:
Source organism: Homo sapiens
Primary publication:
Molecular basis for the recognition of snurportin 1 by importin beta.
J. Biol. Chem. 283 7877-84 (2008)
PMID: 18187419

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 876 amino acids
Theoretical weight: 97.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14974 (Residues: 1-876; Coverage: 100%)
Gene names: KPNB1, NTF97
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Snurportin-1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 40 amino acids
Theoretical weight: 5.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O95149 (Residues: 25-64; Coverage: 11%)
Gene names: RNUT1, SNUPN, SPN1
Sequence domains: Snurportin1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 102.985Å b: 100.696Å c: 108.68Å
α: 90° β: 109.23° γ: 90°
R-values:
R R work R free
0.303 0.303 0.328
Expression systems:
  • Escherichia coli
  • Not provided