PDBe 2pz1

X-ray diffraction
2.25Å resolution

Crystal Structure of Auto-inhibited Asef

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor 4 Chain: A
Molecule details ›
Chain: A
Length: 466 amino acids
Theoretical weight: 53.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NR80 (Residues: 170-632; Coverage: 67%)
Gene names: ARHGEF4, KIAA1112
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID, RIGAKU RU300
Spacegroup: C2
Unit cell:
a: 100.418Å b: 79.883Å c: 67.407Å
α: 90° β: 122.99° γ: 90°
R-values:
R R work R free
0.221 0.217 0.279
Expression system: Escherichia coli