PDBe 2pmv

X-ray diffraction
2.6Å resolution

Crystal Structure of Human Intrinsic Factor- Cobalamin Complex at 2.6 A Resolution

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cobalamin binding intrinsic factor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 399 amino acids
Theoretical weight: 43.45 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: NEW P27352 (Residues: 19-417; Coverage: 100%)
Gene names: CBLIF, GIF, IFMH
Sequence domains: Domain of unknown function (DUF4430)
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 8-BM
Spacegroup: P21
Unit cell:
a: 90.1Å b: 67.3Å c: 147.7Å
α: 90° β: 96.8° γ: 90°
R-values:
R R work R free
0.213 0.213 0.249
Expression system: Komagataella pastoris