PDBe 2pks

X-ray diffraction
2.5Å resolution

Thrombin in complex with inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Thrombin light chain Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 334-360; Coverage: 5%)
Gene name: F2
Thrombin heavy chain Chain: B
Molecule details ›
Chain: B
Length: 147 amino acids
Theoretical weight: 17.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-510; Coverage: 25%)
Gene name: F2
Structure domains: Trypsin-like serine proteases
Thrombin heavy chain Chain: C
Molecule details ›
Chain: C
Length: 102 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 518-619; Coverage: 17%)
Gene name: F2
Structure domains: Trypsin-like serine proteases
Hirudin Chain: D
Molecule details ›
Chain: D
Length: 10 amino acids
Theoretical weight: 1.29 KDa

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU, null
Spacegroup: C2
Unit cell:
a: 69.942Å b: 71.843Å c: 70.778Å
α: 90° β: 100.23° γ: 90°
R-values:
R R work R free
0.188 0.185 0.259