PDBe 2pah

X-ray diffraction
3.1Å resolution

TETRAMERIC HUMAN PHENYLALANINE HYDROXYLASE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phenylalanine-4-hydroxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 38.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P00439 (Residues: 118-452; Coverage: 74%)
Gene name: PAH
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Structure domains: Aromatic amino acid hydroxylase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3112
Unit cell:
a: 119.5Å b: 119.5Å c: 126Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.251 0.326
Expression system: Escherichia coli BL21