PDBe 2p5b

X-ray diffraction
1.99Å resolution

The complex structure of JMJD2A and trimethylated H3K36 peptide

Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lysine-specific demethylase 4A Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 40.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O75164 (Residues: 2-350; Coverage: 33%)
Gene names: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
Sequence domains:
Structure domains: Cupin
Histone H3 Chains: I, J
Molecule details ›
Chains: I, J
Length: 22 amino acids
Theoretical weight: 2.43 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21212
Unit cell:
a: 100.915Å b: 150.844Å c: 57.346Å
α: 90° β: 90° γ: 90°
R R work R free
0.238 0.238 0.263
Expression systems:
  • Escherichia coli
  • Not provided