PDBe 2p1b

X-ray diffraction
2.75Å resolution

Crystal structure of human nucleophosmin-core

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo decamer
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleophosmin Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 122 amino acids
Theoretical weight: 13.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06748 (Residues: 9-122; Coverage: 39%)
Gene names: NPM, NPM1
Sequence domains: Nucleoplasmin/nucleophosmin domain
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 99.262Å b: 107.841Å c: 108.694Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.232
Expression system: Escherichia coli BL21(DE3)