PDBe 2otk

Solution NMR

Structure of Alzheimer Ab peptide in complex with an engineered binding protein

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ZAb3 Affibody dimer Chains: E, F
Molecule details ›
Chains: E, F
Length: 71 amino acids
Theoretical weight: 7.82 KDa
Source organism: engineered binding protein
Expression system: Escherichia coli
Structure domains: Immunoglobulin FC, subunit C
Amyloid-beta protein 40 Chain: C
Molecule details ›
Chain: C
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Ab initio simulated annealing
Expression system: Escherichia coli