PDBe 2oo4

X-ray diffraction
2Å resolution

Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for autoinhibition of Notch.
Nat. Struct. Mol. Biol. 14 295-300 (2007)
PMID: 17401372

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Notch 2 extracellular truncation Chains: A, B
Molecule details ›
Chains: A, B
Length: 234 amino acids
Theoretical weight: 25.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04721 (Residues: 1423-1677; Coverage: 10%)
Gene name: NOTCH2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A, null
Spacegroup: P212121
Unit cell:
a: 45.372Å b: 74.706Å c: 139.412Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.226 0.268
Expression system: Escherichia coli