PDBe 2okj

X-ray diffraction
2.3Å resolution

The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)


Function and Biology Details

Reaction catalysed:
L-glutamate = 4-aminobutanoate + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glutamate decarboxylase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 57.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
  • Canonical: Q99259 (Residues: 93-594; Coverage: 85%)
Gene names: GAD, GAD1, GAD67
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 84.048Å b: 62.739Å c: 101.346Å
α: 90° β: 106.68° γ: 90°
R R work R free
0.188 0.186 0.222
Expression system: Saccharomyces cerevisiae