PDBe 2ocj

X-ray diffraction
2.05Å resolution

Human p53 core domain in the absence of DNA

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the human p53 core domain in the absence of DNA.
Acta Crystallogr. D Biol. Crystallogr. 63 276-81 (2007)
PMID: 17327663

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 219 amino acids
Theoretical weight: 24.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04637 (Residues: 94-312; Coverage: 56%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 68.913Å b: 69.364Å c: 84.179Å
α: 90° β: 90.11° γ: 90°
R-values:
R R work R free
0.209 0.209 0.246
Expression system: Escherichia coli BL21(DE3)