PDBe 2o9i

X-ray diffraction
2.8Å resolution

Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317


Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 1 group I member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 293 amino acids
Theoretical weight: 33.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: NEW O75469 (Residues: 142-434; Coverage: 68%)
Gene names: NR1I2, PXR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.88 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: NEW P70365 (Residues: 686-700; Coverage: 1%)
Gene names: Ncoa1, Src1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 83.979Å b: 90.618Å c: 105.725Å
α: 90° β: 90° γ: 90°
R R work R free
0.228 0.228 0.24
Expression systems:
  • Escherichia coli
  • Not provided