PDBe 2nzt

X-ray diffraction
2.45Å resolution

Crystal structure of human hexokinase II

Released:
Source organism: Homo sapiens
Entry authors: Rabeh WM, Zhu H, Nedyalkova L, Tempel W, Wasney G, Landry R, Vedadi M, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 902 amino acids
Theoretical weight: 100.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52789 (Residues: 17-916; Coverage: 98%)
Gene name: HK2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P212121
Unit cell:
a: 94.89Å b: 129.338Å c: 187.232Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.287
Expression system: Escherichia coli