PDBe 2nyr

X-ray diffraction
2.06Å resolution

Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin


Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
NAD-dependent protein deacylase sirtuin-5, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9NXA8 (Residues: 34-302; Coverage: 87%)
  • Best match: Q9NXA8-4 (Residues: 1-194)
Gene names: SIR2L5, SIRT5
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 41.2Å b: 116.205Å c: 55.993Å
α: 90° β: 90.46° γ: 90°
R R work R free
0.202 0.199 0.269
Expression system: Escherichia coli