PDBe 2nsx

X-ray diffraction
2.11Å resolution

Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease


Function and Biology Details

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Lysosomal acid glucosylceramidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 497 amino acids
Theoretical weight: 55.64 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P04062 (Residues: 40-536; Coverage: 100%)
Gene names: GBA, GC, GLUC
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 108.967Å b: 92.216Å c: 152.67Å
α: 90° β: 110.94° γ: 90°
R R work R free
0.193 0.191 0.235
Expression system: Cricetulus griseus