› 2nao

Solution NMR

Atomic resolution structure of a disease-relevant Abeta(1-42) amyloid fibril

Released:
DOI: 10.2210/pdb2nao/pdb
PDB entry 2nao coloured by chain, ensemble of 10 models, front view.
PDB entry 2nao coloured by chain, ensemble of 10 models, side view.
PDB entry 2nao coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.
Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R
Proc Natl Acad Sci U S A 113 E4976-84 (2016)
PMID: 27469165

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138402 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 42 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 8%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

67 review citations

Functional Amyloids.
Otzen et al. (2019)
66 more

75 mentions without citation

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
74 more