PDBe 2n90

Solution NMR

TrkA transmembrane domain NMR structure in DPC micelles

Source organism: Homo sapiens
Entry authors: Nadezhdin K, Goncharuk S, Arseniev A

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
High affinity nerve growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 39 amino acids
Theoretical weight: 4.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P04629 (Residues: 410-447; Coverage: 5%)
Gene names: MTC, NTRK1, TRK, TRKA
Sequence domains: Tyrosine kinase receptor A trans-membrane domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 52%
Refinement method: simulated annealing
Chemical shifts: BMR25872  
Expression system: Escherichia coli