PDBe 2n83

Solution NMR

p75NTR DD:RIP2 CARD

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor receptor superfamily member 16 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08138 (Residues: 330-427; Coverage: 25%)
Gene names: NGFR, TNFRSF16
Sequence domains: Death domain
Structure domains: Death Domain, Fas
Receptor-interacting serine/threonine-protein kinase 2 Chain: B
Molecule details ›
Chain: B
Length: 106 amino acids
Theoretical weight: 12.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43353 (Residues: 434-539; Coverage: 20%)
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: molecular dynamics
Chemical shifts: BMR25833  
Expression system: Escherichia coli