PDBe 2n5s

Solution NMR

Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 5.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW P00533 (Residues: 642-690; Coverage: 4%)
Gene names: EGFR, ERBB, ERBB1, HER1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: simulated annealing
Chemical shifts: BMR25729  
Expression system: Escherichia coli