PDBe 2n31

Solution NMR

Tom1 negatively modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H0E2 (Residues: 1-53; Coverage: 19%)
Gene name: TOLLIP

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 63%
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING
Chemical shifts: BMR25632  
Expression system: Escherichia coli