PDBe 2n2a

Solution NMR

Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Receptor tyrosine-protein kinase erbB-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P04626 (Residues: 644-700; Coverage: 5%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: simulated annealing
Chemical shifts: BMR25593  
Expression system: Escherichia coli