PDBe 2n19

Solution NMR

STIL binding to the Polo-box domain 3 of PLK4 regulates centriole duplication

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK4 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00444 (Residues: 884-970; Coverage: 9%)
Gene names: PLK4, SAK, STK18
Sequence domains: POLO box duplicated region

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: torsion angle dynamics, molecular dynamics
Chemical shifts: BMR25552  
Expression system: Escherichia coli